The primary research interest of the Lopez laboratory is the role of altered metabolic perturbations, mitochondrial bioenergetics and redox cell regulation in human diseases, including cancer, inborn metabolic diseases in children, preeclampsia and transplant immunology. We have extensive experience measuring metabolic flux, mitochondrial bioenergetics and metabolism, development of mitochondria-targeted antioxidants/pro-drugs and detection of reactive oxygen and nitrogen species in vitro and in vivo. By using a combination of ultra-high-performance liquid chromatography/mass spectrometry and extracellular flux analyzers (Agilent Seahorse), we have developed the ability to understand and provide extremely sensitive and comprehensive views of metabolism and mitochondrial bioenergetics and redox regulation in biological systems and human disease. Over the past few years, we have used these approaches to identify and understand early metabolic perturbations, regulatory mechanisms and metabolic pathways that support the ability of tumor cells (breast, liver & pancreatic cancer) and in diseases like preeclampsia to sustain disease progression and viability in culture and in vivo.
My long-term research interests are aimed to understand the early immunometabolic perturbations controlling disease development, intracellular signaling pathways and redox cell regulation.
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