Lasalde-Dominicci, Jose A.
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Lasalde-Dominicci, Jose A.

Faculty Member

Positions

  • Professor of Biochemistry UPR Rio Piedras Campus, Department of Biology and Chemistry, Adjunct Professor Institute of Neurobiology, Director of the UPR Center for Neuroplasticity, Executive director UPR MSRC, UPR MSRC Scientific Director, Founder and Director of the UPR Clinical Bioreagent Center, Vice president of Research and Technology (2010 2017), Interim President University of Puerto Rico 2013., Universidad de Puerto Rico - Rio Piedras

overview

  • Dr. Jose A. Lasalde Dominicci spent 28 years as a professor of Biochemistry and Biophysics of ion channels at the University of Puerto Rico. Dr. Lasalde Dominicci has a strong background in biochemistry, ion-channel biophysics, electrophysiology, lipid-protein interactions, and nicotinic receptor structure-function relationships.

selected publications

research overview

  • During the past 28 years the research in this NIH-funded laboratory (www.nachrs.org/) has been focused on ion-channel structure, ion-channel lipid interactions, and ion-channel-related disorders. Research areas include: (1) the structure-function relationships of nicotinic receptors, (2), the role of lipid-protein interactions and lipid composition in acetylcholine receptor function, (3) the question of how genetically abnormal ion channels give rise to neurodegeneration in congenital myasthenia, (4) the disruption of the cholinergic anti-inflammatory response (CAR) regulated by a7-nAChRs in macrophages in HIV-seropositive patients, (5) regulation of the 7-neuronal nicotinic receptor in HIV-associated dementia, (6) HIV vaccine development initiative, and (7) studies toward a high-resolution structure of the Torpedo californica nAChR and, more recently, a4b2-nAChR.

full name

  • Jose A. Lasalde-Dominicci

primary email

  • jose.lasalde@upr.edu

phone

  • 787-568-3186
Publications in VIVO
  • Contact Info
  • 787-568-3186
  • Websites